The potential for bidirectional promoter activity of the human PDGF-A chain gene.
نویسندگان
چکیده
Platelet-derived growth factor (PDGF) is a heterodimeric glycoprotein consisting of A and B chains. A functional promoter had been identified in the 5' flanking region of the human PDGF-A chain gene. We found that the PDGF-A chain promoter region possesses the potential for bidirectional activity. This bidirectional promoter activity is influenced by the 5'-untranslated region (5'-UTR) and serum concentration. The 5'-UTR may regulate expression of the PDGF-A chain by transcription in the opposite direction.
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ورودعنوان ژورنال:
- Hiroshima journal of medical sciences
دوره 43 4 شماره
صفحات -
تاریخ انتشار 1994